Brain-penetrating nanoparticles restore neuron function

May 25, 2017

Researchers at the University of Virginia and Johns Hopkins University School of Medicine in Baltimore have developed a new, non-invasive and non-toxic genetic therapeutic technique to restore dopaminergic neuron function in rats suffering from Parkinson’s disease. Read more.

 

Investigator Profile: Q&A with Rich Price, PhD

June 16, 2015

Richard Price, PhD, is a Professor of Biomedical Engineering, Radiation & Radiation Oncology and Research Director of the UVA Focused Ultrasound Center.

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UVA and Hopkins Collaborate to Use FUS to Deliver Nanoparticles into the Brain

 

June 16, 2015

Biomedical engineers at the University of Virginia (UVA) and Johns Hopkins University (JHU) have developed a prolific collaboration that has generated several long-term, multi-million-dollar focused ultrasound research grants.

Richard Price, PhD, Research Director of the UVA Focused Ultrasound Center and Justin Hanes, PhD, Director of the Center for Nanomedicine at the Wilmer Eye Institute and JHU School of Medicine, are developing nanoparticles that can be delivered deep into the brain with the assistance of focused ultrasound. Their work has earned them nearly $7 million of National Institutes of Health (NIH) funding from 2011 to 2020 to propel their discoveries to the clinic.

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Insightec Clinical Head Unit

Getting through to Brain Cancer

Spring 2015

The most common form of brain cancer, glioblastoma, unfortunately is also one of the most deadly and difficult to treat. The statistics are stark: It kills about 95 percent of its victims within five years of diagnosis.

Surgery and radiation have only limited effectiveness because glioblastoma is particularly aggressive, infiltrating brain tissue surrounding the primary tumor. The use of chemotherapy to destroy the invasive tendrils is equally ineffective. The blood–brain barrier — a coating of special cells around capillaries in the brain — keeps everything but a handful of necessary nutrients from crossing to the brain’s extracellular fluid from the blood.

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NIH Awards $3.3 Million Grant to Research Barrier-Breaking Brain Cancer Treatment

 

February 28, 2012

The most common primary brain cancer is glioblastoma, a highly aggressive and deadly form of tumor that kills about 95 percent of its victims within five years of diagnosis.

Like other brain cancers, it is extremely difficult to treat because glioblastomas are usually deeply embedded within healthy brain tissue and therefore nearly impossible to safely access. Chemotherapy drugs cannot reach these tumors because a membrane between the bloodstream and brain tissue, called the blood-brain barrier, blocks them.

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Whoa, Baby! U.Va. Engineering Students Learn Design Process by Building Off-Road Strollers

 

December 9, 2010

Books and lectures are just the starting points for learning how to design and build a new technology. Truly learning engineering design methods requires getting your hands on power tools, and sometimes welding torches.

As part of their first-year “Introduction to Engineering” course, students from the University of Virginia School of Engineering and Applied Science learned the design process by building, and racing, off-road baby strollers.

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